Targeted Delivery of Radioprotective Agents to Mitochondria

Synthesis and Radioprotective Activity of Mitochondria Targeted Dihydropyridines In Vitro

The radiation-induced damage to mitochondrial oxidative respiratory chain could lead to generating of superoxide anions (O2-) and secondary reactive oxygen species (ROS), which are the major resources of continuous ROS production after radiation. Scavenging radiation-induced ROS effectively can help mitochondria to maintain their physiological function and relief cells from oxidative stress. Di...

Radioprotective agents pdf

Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria.

Recent progress in genetics and molecular biology has provided useful information regarding the molecular mechanisms associated with the mitochondrial diseases. Genetic approaches were initiated in the late 1980s to clarify the gene responsible for various mitochondrial diseases, and information concerning genetic mutations is currently used in the diagnosis of mitochondrial diseases. Moreover,...

Targeted Cancer Diagnostic and Therapeutic Agents: Delivery by Carriers or Conjugation

Receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. Specific tumor- targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. Pharmacokinetics and bioavailability of diagnostic and therapeutic agents are ...

Advances in Targeted Drug Delivery